INPP1

INPP1
Identifiers
Aliases	INPP1, inositol polyphosphate-1-phosphatase
External IDs	OMIM: 147263; MGI: 104848; HomoloGene: 1655; GeneCards: INPP1; OMA:INPP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	190,371,665 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	52,856,847 bp
RNA expression pattern
	Top expressed in
	sperm; ; corpus callosum; ; middle frontal gyrus; ; mucosa of pharynx; ; cervix epithelium; ; inferior ganglion of vagus nerve; ; left testis; ; epithelium of nasopharynx; ; right testis; ; duodenum;
	Top expressed in
	granulocyte; ; neural layer of retina; ; cerebellar cortex; ; thymus; ; dentate gyrus of hippocampal formation granule cell; ; spermatid; ; seminal vesicula; ; superior frontal gyrus; ; lobe of cerebellum; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol-1,4-bisphosphate 1-phosphatase activity; inositol-1,3,4-trisphosphate 1-phosphatase activity; hydrolase activity; metal ion binding; protein binding;
Cellular component	cytosol;
Biological process	phosphate-containing compound metabolic process; phosphatidylinositol phosphate biosynthetic process; inositol phosphate metabolic process; signal transduction; dephosphorylation; inositol phosphate dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3628
	16329
	ENSG00000151689
	ENSMUSG00000026102
	P49441
	P49442
	NM_001128928; NM_002194
	NM_008384
	NP_001122400; NP_002185
	NP_032410
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene.^[5]^[6] INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151689 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026102 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ York JD, Veile RA, Donis-Keller H, Majerus PW (Jul 1993). "Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase". Proc Natl Acad Sci U S A. 90 (12): 5833–7. Bibcode:1993PNAS...90.5833Y. doi:10.1073/pnas.90.12.5833. PMC 46817. PMID 8390685.
^ ^a ^b "Entrez Gene: INPP1 inositol polyphosphate-1-phosphatase". Retrieved 2012-07-31.

Majerus PW, Ross TS, Cunningham TW, et al. (1990). "Recent insights in phosphatidylinositol signaling". Cell. 63 (3): 459–65. doi:10.1016/0092-8674(90)90442-H. PMID 2225061. S2CID 29563486.
Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions". Semin. Cell Dev. Biol. 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID 9599410.
Steen VM, Løvlie R, Osher Y, et al. (1998). "The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness". Pharmacogenetics. 8 (3): 259–68. doi:10.1097/00008571-199806000-00008. PMID 9682271.
Løvlie R, Gulbrandsen AK, Molven A, Steen VM (2000). "Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1)". Pharmacogenetics. 9 (4): 517–28. PMID 10780272.
Patel S, Yenush L, Rodríguez PL, et al. (2002). "Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy". J. Mol. Biol. 315 (4): 677–85. doi:10.1006/jmbi.2001.5271. PMID 11812139.
Piccardi MP, Ardau R, Chillotti C, et al. (2002). "Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes". Psychiatr. Genet. 12 (1): 23–7. doi:10.1097/00041444-200203000-00003. PMID 11901356. S2CID 24222446.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151689 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026102 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8390685-5] York JD, Veile RA, Donis-Keller H, Majerus PW (Jul 1993). "Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase". Proc Natl Acad Sci U S A. 90 (12): 5833–7. Bibcode:1993PNAS...90.5833Y. doi:10.1073/pnas.90.12.5833. PMC 46817. PMID 8390685.

[entrez-6] "Entrez Gene: INPP1 inositol polyphosphate-1-phosphatase". Retrieved 2012-07-31.

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References

Further reading