Locus Biosciences

Locus Biosciences
Company typePrivately held company
IndustryPharmaceutical company
FoundedMay 22, 2015; 10 years ago (2015-05-22) in Raleigh, NC, USA
Headquarters
Morrisville, North Carolina
,
United States
Key people
Websitewww.locus-bio.com

Locus Biosciences (Locus) is a clinical-stage pharmaceutical company, founded in 2015 and based in Research Triangle Park (RTP), North Carolina.[1] Locus developed an AI-enabled precision medicine platform, enabling the company to develop engineered bacteriophage (phage) therapies[2] that are designed to selectively remove particular pathogenic bacterial species from the body while leaving other non-target bacteria unaffected. Locus is advancing products to treat antibiotic-resistant bacterial infections[2] and to treat other bacteria-driven diseases such as Crohn's disease.

History

The company was founded based on CRISPR-Cas3 technology licensed from North Carolina State University (NCSU) in 2015.[3] Initial funding for the company came from founder Paul Garofolo, the North Carolina Biotechnology Center, and private investors.[4]

In 2017, the company closed a $19 million Series A financing led by Artis Ventures.[4][5] This financing funded development of the company's engineered bacteriophage platform technology and preclinical development of Locus's first product.

In 2018, Locus acquired a high-throughput bacteriophage discovery platform from San Francisco-based phage therapy company EpiBiome, Inc.[6][7] This acquisition dramatically expanded the scale of Locus's platform, enabling the company to discover thousands of bacteriophage for each development program and to optimize phage cocktails using artificial intelligence and machine learning tools.

In 2019, the company entered into a strategic collaboration with Janssen Pharmaceuticals (a Johnson & Johnson company) to develop engineered bacteriophage therapies targeting Pseudomonas and Staphylococcus bacteria.[8][9][10][11] Under that contract, Locus was entitled to receive $20 million upfront, up to $798 million in milestone payments, and royalties on net product sales.[12]

In 2020, Locus signed a $77 million contract as part of a $144 million collaboration with the Biomedical Advanced Research and Development Authority (BARDA), part of the United States Department of Health and Human Services, to develop LBP-EC01, an engineered bacteriophage therapy designed to treat urinary tract infections caused by antibiotic resistant strains of Escherichia coli bacteria.[13]

Also in 2020, the company signed a $12.5 million contract with the global non-profit Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) to fund development of an engineered bacteriophage product targeting Klebsiella pneumoniae bacteria.[14]

In 2022, Locus closed a $35 million Series B financing with participation from existing investors such as Artis Ventures and Viking Global Investors along with new investors such as the Johnson & Johnson Development Corporation (JJDC).[15]

Phage injecting its genome into bacterial cell

LOCUS Platform

Locus develops its products by combining high-throughput automated phage discovery, AI-driven phage cocktail optimization, synthetic biology, and a state-of-the-art viral vector manufacturing facility to create precision medicines targeting particular pathogenic bacterial species.

The company's synthetic biology approach engineers phage isolated from nature with payloads to enable them to kill target bacteria more effectively than their natural counterparts. Locus's initial products utilized CRISPR-Cas3 payloads, which enhance the killing capability of phage by degrading the target bacteria's genomic DNA.[16][17][18] The company has since added additional payloads that work through various mechanisms.

Clinical development

The company enrolled its first patient in a Phase 1b clinical trial for LBP-EC01 in 2020[19][20] and successfully completed the trial in 2021.[21] Locus subsequently announced positive results from Part 1 of a two-part Phase 2 clinical trial of LBP-EC01, which was published in The Lancet Infectious Diseases.[22] These positive results resulted in $23.9 million additional funding from BARDA to support Part 2 of the Phase 2 clinical trial.[23]

Publications

  • Kim, Paul; Sanchez, Ana M.; Penke, Taylor J. R.; Tuson, Hannah H.; Kime, James C.; McKee, Robert W.; Slone, William L.; Conley, Nicholas R.; McMillan, Lana J.; Prybol, Cameron J.; Garofolo, Paul M. (August 9, 2024). "Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial". The Lancet Infectious Diseases. 24 (12): 1319–1332. doi:10.1016/S1473-3099(24)00424-9. PMID 39134085.

References

  1. ^ Eanes, Zachery (March 9, 2021). "Locus using gene-editing technology to get ahead of drug-resistant bacteria". The Herald-Sun. pp. B4. Retrieved August 19, 2022 – via Newspapers.com.
  2. ^ a b Gibney, Elizabeth (January 2, 2018). "What to expect in 2018: science in the new year". Nature. 553 (7686): 12–13. Bibcode:2018Natur.553...12G. doi:10.1038/d41586-018-00009-5. PMID 29300040.
  3. ^ Brown, Kristen V. (February 24, 2017). "Scientists Are Creating a Genetic Chainsaw to Hack Superbug DNA to Bits". Gizmodo. G/O Media. Archived from the original on December 9, 2018. Retrieved July 18, 2020.
  4. ^ a b Martz, Lauren (August 31, 2017). "Cutting through resistance". Biocentury. Retrieved July 18, 2020.
  5. ^ Maurer, Allan (November 19, 2020). "Gene editing success could turn Triangle startup Locus Biosciences into a billion dollar unicorn". WRAL TechWire. Capitol Broadcasting Company.
  6. ^ "Locus Biosciences Acquires EpiBiome Bacteriophage Discovery Platform". Genomeweb. July 17, 2018. Retrieved February 27, 2019.
  7. ^ "CRISPR-Cas3 Platform Developer Locus Biosciences Acquires EpiBiome Phage Technology". Genetic Engineering & Biotechnology Nerws. July 17, 2018.
  8. ^ Shieber, Jonathan (January 4, 2019). "Up to $818 million deal between J&J and Locus Biosciences points to a new path for CRISPR therapies". TechCrunch. Archived from the original on February 3, 2019. Retrieved March 8, 2019.
  9. ^ Taylor, Phil (January 3, 2019). "J&J takes stake in Locus' CRISPR-based 'Pac-Man' antimicrobials". Fierce Biotech. Archived from the original on March 6, 2019. Retrieved February 27, 2019.
  10. ^ Molteni, Megan (January 16, 2019). "Antibiotics Are Failing Us. Crispr is Our Glimmer of Hope". Wired. Archived from the original on January 23, 2019. Retrieved March 8, 2019.
  11. ^ Schmidt, Charles (November 1, 2019). "Is Phage Therapy Here to Stay?". Scientific American. 321 (5): 50–57. doi:10.1038/scientificamerican1119-50. Retrieved October 23, 2019.
  12. ^ Brown, Kristen (January 3, 2019). "J&J Bets $20 Million on DNA Tool to Battle Infectious Bacteria". Bloomberg. Retrieved February 27, 2019.
  13. ^ Biosciences, Locus. "Locus Biosciences signs contract with BARDA to advance $144 million precision medicine program to develop LBP-EC01, a crPhage™ product". www.prnewswire.com. Retrieved July 25, 2025.
  14. ^ "CARB-X is funding Locus Biosciences to develop an innovative CRISPR Cas-3-enhanced bacteriophage targeting antibiotic-resistant Klebsiella pneumoniae infections". Carb-X. Retrieved July 25, 2025.
  15. ^ Jane Byrne (May 19, 2022). "Bacteriophage producer Locus Biosciences raises $35m in financing". BioPharma Reporter.
  16. ^ Marcus, Amy Dockser. "A Genetic 'Chain Saw' to Target Harmful DNA". Wall Street Journal. Archived from the original on March 6, 2018. Retrieved February 27, 2019.
  17. ^ Sinkunas T, Gasiunas G, Fremaux C, Barrangou R, Horvath P, Siksnys V (April 2011). "Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system". The EMBO Journal. 30 (7): 1335–42. doi:10.1038/emboj.2011.41. PMC 3094125. PMID 21343909.
  18. ^ Huo Y, Nam KH, Ding F, Lee H, Wu L, Xiao Y, Farchione MD, Zhou S, Rajashankar K, Kurinov I, Zhang R, Ke A (September 2014). "Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation". Nature Structural & Molecular Biology. 21 (9): 771–7. doi:10.1038/nsmb.2875. PMC 4156918. PMID 25132177.
  19. ^ "Locus Biosciences initiates world's first controlled clinical trial for a CRISPR enhanced bacteriophage therapy". January 8, 2020. Retrieved January 11, 2020.
  20. ^ "The First Controlled Clinical Trial For A CRISPR Enhanced Bacteriophage Therapy". www.clinicalleader.com. Archived from the original on December 9, 2024. Retrieved July 25, 2025.
  21. ^ Biosciences, Locus (February 24, 2021). "Locus Biosciences completes first-of-its-kind controlled clinical trial for CRISPR-enhanced bacteriophage therapy". GlobeNewswire News Room. Retrieved July 25, 2025.
  22. ^ Kim, Paul; Sanchez, Ana M.; Penke, Taylor J. R.; Tuson, Hannah H.; Kime, James C.; McKee, Robert W.; Slone, William L.; Conley, Nicholas R.; McMillan, Lana J.; Prybol, Cameron J.; Garofolo, Paul M. (December 1, 2024). "Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial". The Lancet Infectious Diseases. 24 (12): 1319–1332. doi:10.1016/S1473-3099(24)00424-9. ISSN 1473-3099. PMID 39134085.
  23. ^ "Locus Biosciences receives $23.9 million from BARDA for CRISPR-engineered therapy trial | North Carolina Biotechnology Center". www.ncbiotech.org. Retrieved July 25, 2025.
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